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In the 12-month TRANSFORMS trial, 1292 patients with relapsing-remitting multiple sclerosis were randomly assigned in a double-dummy, double-blind design to fingolimod 1.25 mg oral daily, fingolimod 0.5 mg oral daily, or interferon beta-1a 30 mcg intramuscular weekly

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Apart from GHR2 , which shows no preferential expression, the genes are each predominantly expressed in a particular organ, roots for GHR1 , senescent leaves for GHR3 and mature seeds for GHR4 (Figure 4)